一道英语语法填空题This means their children will for sure have the family disease,____ ,as a matter of fact,is a great trouble for these families.填meanwhile对不对?若不对答案是什么?

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一道英语语法填空题This means their children will for sure have the family disease,____ ,as a matter of fact,is a great trouble for these families.填meanwhile对不对?若不对答案是什么?
一道英语语法填空题
This means their children will for sure have the family disease,____ ,as a matter of fact,is a great trouble for these families.
填meanwhile对不对?若不对答案是什么?

一道英语语法填空题This means their children will for sure have the family disease,____ ,as a matter of fact,is a great trouble for these families.填meanwhile对不对?若不对答案是什么?
不对呀,应该填which,因为这里as a matter of fact是插入语,事实是……,如果把这个短语去掉,就是This means their children will for sure have the family disease,is a great trouble for these families.
这里显然是定语从句缺少一个引导词,而且这个引导词在定语从句里要做主语,所以应该填which,而不应该填连词.

cherry回答的是对的，我再补充一点，即便把as a matter of fact这个插入语去掉，也应该填which，因为as a matter of fact前有逗号，这是非限制性定语从句的标志，只能用which。而且又有了as a matter of fact这个插入语，有插入语的定语从句，加的一定是which

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